Can Lamotrigine be taken with Escitlaporam for major depression?

Yes you can take them both. Lamotrigine is primarily used to control seizures, but also work very well as a mood stabiliser which also has excellent antidepressant properties. Your Doctor would have advised you when to take in the medication so you can fully benefit from it. Obviously this depends on what time you get up and what time you go to bed. I take Lamotrigine along with Lithium and Seroquel XL.